Computing has become an integral part of everyday practice within modern fields of science, technology, engineering, and math (STEM). As a result, the STEM+Computing Partnerships (STEM+C) program seeks to advance new approaches to, and evidence-based understanding of, the integration of computing in STEM teaching and learning. Computational Thinking (CT) is an intellectual skill rooted in the ability to conceive of meaningful, information-based representations that can be effectively manipulated by a computer. Integrating CT into core science instruction addresses practical constraints in K-12 education, in that there is no room in the curriculum to teach it directly to everyone. But, more importantly, integrating CT into core science provides a synergistic opportunity to deepen instruction in both.